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Postdoctoral fellow
Dr. Hassan Fazilaty
Office Y55-L-70
Tel +41 44 635 31 26
Brief CV
08.2019-present, Postdoctoral fellow, Lab of Professor Konrad Basler, Institute of Molecular Life Sciences, University of Zurich, Zürich, Switzerland
04.2019-08.2019, Postdoctoral researcher, Lab of Professor M. Angela Nieto, Instituto de Neurociencias CSIC-UMH, San Juan de Alicante, Spain
09.2014-04.2019, Doctor of Philosophy (Ph.D.), Lab of Professor M. Angela Nieto, Instituto de Neurociencias CSIC-UMH, San Juan de Alicante, Spain & School of Medicine, Universidad Autonoma de Madrid (UAM), Madrid, Spain
09.2011-08.2014, Master of Science (M.Sc.) in Human Genetics, Department of Medical Genetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
Research
09.2014-07.2019, Research scholar, Instituto de Neurociencias CSIC-UMH, San Juan de Alicante, Spain
05.2013-08.2014, Clinical Genetics research scholar, Genetic unit, eye research center, Rasoul Akram Medical Complex, Tehran, Iran
01.2013-08.2014, Research scholar, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
Outreach
02.09.2023, Scientifica, University of Zurich, Zurich, Switzerland, short lecture:
Hijacked and Reprogrammed by Cancer Cells - Scientifica
Fellowship/funding
01.2023-12.2025, 3RCC grant (3Rs Doctorate Program: DP-2022-003) to Tosca Dalessi, Hassan Fazilaty, Tomas Valenta and Konrad Basler, Zurich, Switzerland (CHF 170'000.00) Cre-Rux - improving mouse well-being with a refined approach for in vivo genetic manipulation
12.2021-11.2021, Forschungskredit Postdoc fellowship, University of Zurich, Zurich, Switzerland
08.2021, 2 years 3RCC grant (Project OC-2020-011) to Jamie Little, Konrad Basler, Erich Brunner and Hassan Fazilaty, Switzerland
11.2019-11.2021, 2 years fellowship of Cancer Research Center Zurich (CRC funding) to Prof. Konrad Basler and Prof. Gerhard Rogler, University of Zurich (UZH) and University Hospital Zurich (USZ), Switzerland
09.2014-08.2017, 3 years fellowship award, Santiago Grisolia (GRISOLIA / 2014/004) Resolution of 3 June 2014, Generalitat Valenciana, Alicante, Spain
08.2013, Grant # 92003378 from Iran National Science Foundation (INSF) to Dr. Babak Behnam and Hassan Fazilaty
06.2013, Grant from Iran University of Medical Sciences (IUMS) to Dr. Babak Behnam and Hassan Fazilaty
Selected Publications
Fazilaty H* and Basler K. Reactivation of embryonic gene-expression programs in tissue regeneration and disease. Nature Genetics 2023 epub |https://10.1038/s41588-023-01526-4.
Berková L, Fazilaty H, Yang Q, Kubovciak J, Stastna M. Hrckulak D, Vojtechova M, Dalessi T, Brügger MD, Hausmann G, Liberal P, Korinek V, Basler K*, Valenta T*. Terminal differentiation of villus-tip enterocytes is governed by distinct TGFβ superfamily members. EMBO Reports 2023 24:e56454 |https://10.15252/embr.202256454.
Fazilaty H. Restoration of embryonic gene expression patterns in tissue regeneration and disease. Nat Rev Mol Cell Biol 2023 Feb 16. |https://10.1038/s41580-023-00586-y.
Fazilaty H*, Brügger M*, Valenta T* Szczerba BM, Berkova L, Doumpas N, Hausmann G, Scharl M and Basler K. Tracing colonic embryonic transcriptional profile and tracking their reactivation in inflammatory disease at single cell level. Cell Reports 36, 109484. 2021 Aug 03. |https://doi.org/10.1016/j.celrep.2021.109484.
Brügger M*, Valenta T*, Fazilaty H*, Hausmann G, Basler K*. Distinct populations of crypt-associated fibroblasts act as signaling hubs to control colon homeostasis. Plos Biology 2020 Dec 11. |https://doi.org/10.1371/journal.pbio.3001032.
Fazilaty H, Rago L, Youssef KK, Ocana O, Garcia-Asencio F, Arcas A, Galceran J, Nieto MA. A Gene Regulatory Network to Control EMT Programs in Development and Disease. Nature Communications 2019 10:5115 |https://doi.org/10.1038/s41467-019-13091-8.
Rago L, Castroviejo N, Fazilaty H, Garcia-Asencio F, Galceran J, Nieto MA. MicroRNAs establish the right-handed dominance of the heart laterality pathway in vertebrates. Developmental Cell 2019 Oct 17. pii: S1534-5807(19)30768-3. | https://doi.org/10.1016/j.devcel.2019.09.012.
Fazilaty H, Gardaneh M, Akbari P, Zekri A, Behnam B. SLUG and SOX9 cooperatively regulate metastatic niche factors in breast cancer. Cancer Microenvironment 2015 September doi: https://doi.org/10.1007/s12307-015-0176-8.
Fazilaty H, Mehdipour P*. Genetics of breast cancer bone metastasis; a sequential multistep pattern. Clinical & Experimental Metastasis 2014 31:595-612 |https://doi:10.1007/s10585-014-9642-9.
Fazilaty H, Gardaneh M, Bahrami T, Salmaninejad A, and Behnam B. Crosstalk between breast cancer stem cells and metastatic niche: emerging molecular metastasis pathway? Tumor Biology 2013 Aug; 34(4):2019-30. doi: https://doi.org/10.1007/s13277-013-0831-y.
*Equal contribution.
Book chapters
Behnam B, Fazilaty H, Roghanian A, The Importance of Circulating Tumor Cells and Tumor Models in Future of Cancer Therapy (book title: Ex Vivo Engineering of the Tumor Microenvironment, pp. 121-135, Editors Aref, A. and Barbie D. (eds.)). Springer International Publishing Switzerland 2017, DOI 10.1007/978-3-319-45397-2_7
Fazilaty H, Mehdipour P. Retinic Acid Receptor-beta, from gene to clinic. (In book: Epigenetics Territory and Cancer, pp.363-372, Editor Parvin Mehdipour). Springer Science+Business Media Dordrecht 2015. DOI 10.1007/978-94-017-9639-2_12
PubMed link: https://pubmed.ncbi.nlm.nih.gov/?term=fazilaty+h&sort=date