Publications

ZORA Publication List

Publications

2023

• 2023

  • Journal Article

    • He, Jiazhuo; Nascakova, Zuzana; Leary, Peter; Papa, Giovanni; Valenta, Tomas; Basler, Konrad; Müller, Anne (2023). Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells. Science Advances, 9(46):eadh0322.
    • Brügger, Michael David; Basler, Konrad (2023). The diverse nature of intestinal fibroblasts in development, homeostasis, and disease. Trends in Cell Biology, 33(10):834-849.
    • Berková, Linda; Fazilaty, Hassan; Yang, Qiutan; Kubovčiak, Jan; Stastna, Monika; Hrckulak, Dusan; Vojtechova, Martina; Dalessi, Tosca; Brügger, Michael David; Hausmann, George; Liberali, Prisca; Korinek, Vladimir; Basler, Konrad; Valenta, Tomas (2023). Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members. EMBO Reports, 24(9):e56454.
    • Kim, Jong-Myeong; Min, Kwang Wook; Kim, You-Joung; Smits, Ron; Basler, Konrad; Kim, Jin Woo (2023). Wnt/β-Catenin Signaling Pathway Is Necessary for the Specification but Not the Maintenance of the Mouse Retinal Pigment Epithelium. Molecules and Cells, 46(7):441-450.
    • Gurtner, Alessandra; Borrelli, Costanza; Gonzalez-Perez, Ignacio; Bach, Karsten; Acar, Ilhan E; Núñez, Nicolás G; Crepaz, Daniel; Handler, Kristina; Vu, Vivian P; Lafzi, Atefeh; Stirm, Kristin; Raju, Deeksha; Gschwend, Julia; Basler, Konrad; Schneider, Christoph; Slack, Emma; Valenta, Tomas; Becher, Burkhard; Krebs, Philippe; Moor, Andreas E; Arnold, Isabelle C (2023). Active eosinophils regulate host defense and immune responses in colitis. Nature, 615(7950):151-157.
    • Häfliger, Janine; Schwarzfischer, Marlene; Atrott, Kirstin; Stanzel, Claudia; Morsy, Yasser; Wawrzyniak, Marcin; Lang, Silvia; Valenta, Tomas; Basler, Konrad; Rogler, Gerhard; Scharl, Michael; Spalinger, Marianne R (2023). Glycoprotein (GP)96 is essential for maintaining intestinal epithelial architecture by supporting its self-renewal capacity. Cellular and Molecular Gastroenterology and Hepatology, 15(3):717-739.
2022

• 2022

  • Journal Article

    • Maruyama, Takamitsu; Hasegawa, Daigaku; Valenta, Tomas; Haigh, Jody; Bouchard, Maxime; Basler, Konrad; Hsu, Wei (2022). GATA3 mediates nonclassical β-catenin signaling in skeletal cell fate determination and ectopic chondrogenesis. Science Advances, 8(48):eadd6172.
2021

• 2021

  • Journal Article

    • Degirmenci, Bahar; Dincer, Cansu; Demirel, Habibe Cansu; Berkova, Linda; Moor, Andreas E; Kahraman, Abdullah; Hausmann, George; Aguet, Michel; Tuncbag, Nurcan; Valenta, Tomas; Basler, Konrad (2021). Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model. iScience, 24(12):103369.
    • Borrelli, Costanza; Valenta, Tomas; Handler, Kristina; Vélez, Karelia; Gurtner, Alessandra; Moro, Giulia; Lafzi, Atefeh; De Vargas Roditi, Laura; Hausmann, George; Arnold, Isabelle C; Moor, Andreas E; Basler, Konrad (2021). Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells. Nature Communications, 12:1368.
    • Doumpas, Nikolaos; Söderholm, Simon; Narula, Smarth; Moreira, Steven; Doble, Bradley W; Cantù, Claudio; Basler, Konrad (2021). TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state. Cell Reports, 36(11):109705.
    • Diener, Johanna; Baggiolini, Arianna; Pernebrink, Mattias; Dalcher, Damian; Lerra, Luigi; Cheng, Phil F; Varum, Sandra; Häusel, Jessica; Stierli, Salome; Treier, Mathias; Studer, Lorenz; Basler, Konrad; Levesque, Mitchell P; Dummer, Reinhard; Santoro, Raffaella; Cantù, Claudio; Sommer, Lukas (2021). Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4. Nature Communications, 12(1):5056.
    • Fazilaty, Hassan; Brügger, Michael David; Valenta, Tomas; Szczerba, Barbara M; Berkova, Linda; Doumpas, Nikolaos; Hausmann, George; Scharl, Michael; Basler, Konrad (2021). Tracing colonic embryonic transcriptional profiles and their reactivation upon intestinal damage. Cell Reports, 36(5):109484.
2020

• 2020

  • Journal Article

    • Brügger, Michael David; Valenta, Tomas; Fazilaty, Hassan; Hausmann, George; Basler, Konrad (2020). Distinct populations of crypt-associated fibroblasts act as signaling hubs to control colon homeostasis. PLoS Biology, 18(12):e3001032.
    • Saxena, Meera; Kalathur, Ravi KR; Rubinstein, Natalia; Vettiger, Andrea; Sugiyama, Nami; Neutzner, Melanie; Coto-Llerena, Mairene; Kancherla, Venkatesh; Ercan, Caner; Piscuoglio, Salvatore; Fischer, Jonas; Fagiani, Ernesta; Cantù, Claudio; Basler, Konrad; Christofori, Gerhard (2020). A Pygopus 2-histone interaction is critical for cancer cell de-differentiation and progression in malignant breast cancer. Cancer Research, 80(17):3631-3648.
    • Bosch, Pablo Sanchez; Pepperl, Julia; Basler, Konrad (2020). Anchor away – A fast, reliable and reversible technique to inhibit proteins in Drosophila melanogaster. G3 : Genes, Genomes, Genetics, 10(5):1745-1752.
    • Cannac, Fabien; Qi, Chao; Falschlunger, Julia; Hausmann, George; Basler, Konrad; Korkhov, Volodymyr M (2020). Cryo-EM structure of the hedgehog release protein dispatched. Science Advances, 6(16):eaay7928.

  • Working Paper

    • Borrelli, Costanza; Valenta, Tomas; Handler, Kristina; Vélez, Karelia; Moro, Giulia; Lafzi, Atefeh; de Vargas Roditi, Laura; Hausmann, George; Moor, Andreas E; Basler, Konrad (2020). Discrete regulation of β-catenin-mediated transcription governs identity of intestinal epithelial stem cells. bioRxiv 103499, Cold Spring Harbor Laboratory.
    • Zimmerli, Dario; Borrelli, Costanza; Jauregi-Miguel, Amaia; Söderholm, Simon; Brütsch, Salome; Doumpas, Nikolaos; Reichmuth, Jan; Murphy-Seiler, Fabienne; Aguet, Michel; Basler, Konrad; Moor, Andreas E; Cantù, Claudio (2020). TBX3 acts as tissue-specific component of the Wnt/β-catenin enhanceosome. bioRxiv 053561, Cold Spring Harbor Laboratory.
2019

• 2019

  • Journal Article

    • Kabakci, Zeynep; Käppeli, Simon; Cantù, Claudio; Jensen, Lasse D; König, Christiane; Toggweiler, Janine; Gentili, Christian; Ribaudo, Giovanni; Zagotto, Giuseppe; Basler, Konrad; Pinna, Lorenzo A; Cozza, Giorgio; Ferrari, Stefano (2019). Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and tumor regression. Scientific Reports, 9(1):1335.
    • Brunner, Erich; Yagi, Ryohei; Debrunner, Marc; Beck-Schneider, Dezirae; Burger, Alexa; Escher, Eliane; Mosimann, Christian; Hausmann, George; Basler, Konrad (2019). CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms. Life Science Alliance, 2(3):e201800267.
    • Zurkirchen, Luis; Varum, Sandra; Giger, Sonja; Klug, Annika; Häusel, Jessica; Bossart, Raphaël; Zemke, Martina; Cantù, Claudio; Atak, Zeynep Kalender; Zamboni, Nicola; Basler, Konrad; Sommer, Lukas (2019). Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Nature Communications, 10:2192.
    • Varum, Sandra; Baggiolini, Arianna; Zurkirchen, Luis; Atak, Zeynep Kalender; Cantù, Claudio; Marzorati, Elisa; Bossart, Raphaël; Wouters, Jasper; Häusel, Jessica; Tuncer, Eylül; Zingg, Daniel; Veen, Dominiek; John, Nessy; Balz, Marcel; Levesque, Mitchell P; Basler, Konrad; Aerts, Stein; Zamboni, Nicola; Dummer, Reinhard; Sommer, Lukas (2019). Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Cell Stem Cell, 24(4):637-653.e9.
    • Shokri, Leila; Inukai, Sachi; Hafner, Antonina; Weinand, Kathryn; Hens, Korneel; Vedenko, Anastasia; Gisselbrecht, Stephen S; Dainese, Riccardo; Bischof, Johannes; Furger, Edy; Feuz, Jean-Daniel; Basler, Konrad; Deplancke, Bart; Bulyk, Martha L (2019). A Comprehensive Drosophila melanogaster Transcription Factor Interactome. Cell Reports, 27(3):955-970.e7.
    • Doumpas, Nikolaos; Lampart, Franziska; Robinson, Mark D; Lentini, Antonio; Nestor, Colm E; Cantù, Claudio; Basler, Konrad (2019). TCF/LEF dependent and independent transcriptional regulation of Wnt/β-catenin target genes. EMBO Journal Online, 38(2):e98873.
2018

• 2018

  • Journal Article

    • Baillon, Ludovic; Germani, Federico; Rockel, Claudia; Hilchenbach, Jochen; Basler, Konrad (2018). Xrp1 is a transcription factor required for cell competition-driven elimination of loser cells. Scientific Reports, 8(1):17712.
    • Germani, Federico; Hain, Daniel; Sternlicht, Denise; Moreno, Eduardo; Basler, Konrad (2018). The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner. eLife, 7:e39939.
    • Cantù, Claudio; Felker, Anastasia; Zimmerli, Dario; Prummel, Karin D; Cabello, Elena M; Chiavacci, Elena; Méndez-Acevedo, Kevin M; Kirchgeorg, Lucia; Burger, Sibylle; Ripoll, Jorge; Valenta, Tomas; Hausmann, George; Vilain, Nathalie; Aguet, Michel; Burger, Alexa; Panáková, Daniela; Basler, Konrad; Mosimann, Christian (2018). Mutations in and genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling. Genes and Development, 32(21-22):1443-1458.
    • Wang, Yidong; Lu, Pengfei; Wu, Bingruo; Riascos-Bernal, Dario F; Sibinga, Nicholas E S; Valenta, Tomas; Basler, Konrad; Zhou, Bin (2018). Myocardial β-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation. Journal of Molecular and Cellular Cardiology, 123:150-158.
    • Bischof, Johannes; Duffraisse, Marilyne; Furger, Edy; Ajuria, Leiore; Giraud, Guillaume; Vanderperre, Solene; Paul, Rachel; Björklund, Mikael; Ahr, Damien; Ahmed, Alexis W; Spinelli, Lionel; Brun, Christine; Basler, Konrad; Merabet, Samir (2018). Generation of a versatile BiFC ORFeome library for analyzing protein-protein interactions in live. eLife, 7:e38853.
    • Zingg, Daniel; Debbache, Julien; Peña-Hernández, Rodrigo; Antunes, Ana T; Schaefer, Simon M; Cheng, Phil F; Zimmerli, Dario; Haeusel, Jessica; Calçada, Raquel R; Tuncer, Eylul; Zhang, Yudong; Bossart, Raphaël; Wong, Kwok-Kin; Basler, Konrad; Dummer, Reinhard; Santoro, Raffaella; Levesque, Mitchell P; Sommer, Lukas (2018). EZH2-mediated primary cilium deconstruction drives metastatic melanoma formation. Cancer Cell, 34(1):69-84.
    • Degirmenci, Bahar; Valenta, Tomas; Dimitrieva, Slavica; Hausmann, George; Basler, Konrad (2018). GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells. Nature, 558(7710):449-453.
    • Spletter, Maria L; Barz, Christiane; Yeroslaviz, Assa; Zhang, Xu; Lemke, Sandra B; Bonnard, Adrien; Brunner, Erich; Cardone, Giovanni; Basler, Konrad; Habermann, Bianca H; Schnorrer, Frank (2018). A transcriptomics resource reveals a transcriptional transition during ordered sarcomere morphogenesis in flight muscle. eLife, 7:e34058.
    • Zimmerli, Dario; Cecconi, Virginia; Valenta, Tomas; Hausmann, George; Cantù, Claudio; Restivo, Gaetana; Hafner, Jürg; Basler, Konrad; van den Broek, Maries (2018). WNT ligands control initiation and progression of human papillomavirus-driven squamous cell carcinoma. Oncogene, 37(27):3753-3762.
    • Degirmenci, Bahar; Hausmann, George; Valenta, Tomas; Basler, Konrad (2018). Wnt Ligands as a Part of the Stem Cell Niche in the Intestine and the Liver. Progress in molecular biology and translational science, 153:1-19.
2017

• 2017

  • Journal Article

    • Franz, Alexandra; Brunner, Erich; Basler, Konrad (2017). Generation of genome-modified Drosophila cell lines using SwAP. Fly, 11(4):303-311.
    • Marty, Florian; Rago, Gianluca; Smith, Donald F; Gao, Xiaoli; Eijkel, Gert B; MacAleese, Luke; Bonn, Mischa; Brunner, Erich; Basler, Konrad; Heeren, Ron M A (2017). Combining ToF-SIMS imaging mass spectrometry and CARS microspectroscopy reveals lipid patterns reminiscent of gene expression patterns in the wing imaginal disc of Drosophila melanogaster. Analytical Chemistry, 89(18):9664-9670.
    • Sanchez Bosch, Pablo; Ziukaite, Ruta; Alexandre, Cyrille; Basler, Konrad; Vincent, Jean-Paul (2017). Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action. eLife, 6:e22546.
    • Zimmerli, Dario; Hausmann, George; Cantù, Claudio; Basler, Konrad (2017). Pharmacological interventions in the Wnt pathway: Inhibition of Wnt secretion versus disrupting the protein-protein interfaces of nuclear factors. British Journal of Pharmacology, 174(24):4600-4610.
    • Blyszczuk, Przemyslaw; Müller-Edenborn, Björn; Valenta, Tomas; Osto, Elena; Stellato, Mara; Behnke, Silvia; Glatz, Katharina; Basler, Konrad; Lüscher, Thomas F; Distler, Oliver; Eriksson, Urs; Kania, Gabriela (2017). Transforming growth factor-β-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. European Heart Journal, 38(18):1413-1425.
    • Franz, Alexandra; Shlyueva, Daria; Brunner, Erich; Stark, Alexander; Basler, Konrad (2017). Probing the canonicity of the Wnt/Wingless signaling pathway. PLoS Genetics, 13(4):e1006700.
    • Cantù, Claudio; Pagella, Pierfrancesco; Shajiei, Tania D; Zimmerli, Dario; Valenta, Tomas; Hausmann, George; Basler, Konrad; Mitsiadis, Thimios A (2017). A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation. Science Signaling, 10(465):eaah4598.
    • Eder, Dominik; Basler, Konrad; Aegerter, Christof M (2017). Challenging FRET-based E-Cadherin force measurements in Drosophila. Scientific Reports, 7:13692.
    • Eder, Dominik; Aegerter, Christof; Basler, Konrad (2017). Forces controlling organ growth and size. Mechanisms of Development, 144:53-61.
2016

• 2016

  • Journal Article

    • Toggweiler, Janine; Willecke, Maria; Basler, Konrad (2016). The transcription factor Ets21C drives tumor growth by cooperating with AP-1. Scientific Reports, 6:34725.
    • Cantù, Claudio; Zimmerli, Dario; Basler, Konrad (2016). Unexpected survival of mice carrying a mutation in Pygo2 that strongly reduces its binding to Bcl9/9l. Matters Select:1-5.
    • Valenta, Tomas; Degirmenci, Bahar; Moor, Andreas E; Herr, Patrick; Zimmerli, Dario; Moor, Matthias B; Hausmann, George; Cantù, Claudio; Aguet, Michel; Basler, Konrad (2016). Wnt ligands secreted by subepithelial mesenchymal cells are essential for the survival of intestinal stem cells and gut homeostasis. Cell Reports, 15:1-8.
    • Heller, Davide; Hoppe, Andreas; Restrepo, Simon; Gatti, Lorenzo; Tournier, Alexander L; Tapon, Nicolas; Basler, Konrad; Mao, Yanlan (2016). EpiTools: An Open-Source Image Analysis Toolkit for Quantifying Epithelial Growth Dynamics. Developmental Cell, 36(1):103-116.
    • Jenny, Fabian H; Basler, Konrad (2016). Drosophila DDX3/Belle exerts its function outside of the Wnt/Wingless signaling pathway. PLoS ONE, 11(12):e0166862.
    • Restrepo, Simon; Zartman, Jeremiah J; Basler, Konrad (2016). Cultivation and Live Imaging of Drosophila Imaginal Discs. Methods in Molecular Biology, 1478:203-213.
    • Restrepo, Simon; Basler, Konrad (2016). Drosophila wing imaginal discs respond to mechanical injury via slow InsP3R-mediated intercellular calcium waves. Nature Communications, 7:12450.
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