Address

Department of Molecular Life Sciences
Winterthurerstrasse 190
CH-8057 Zurich
Switzerland

Administration office: Y32-J-12
Sabina Steiner
Phone: +41 44 635 48 73

The FDA-approved Drug Nelfinavir Inhibits Lytic Cell-Free, but Not Cell-Associated Non-Lytic Transmission of Human Adenovirus

Adenoviruses (AdVs) are prevalent and give rise to chronic and recurrent disease. The human AdV (HAdV) species B and C, such as HAdV-C2, C5 and B14, cause respiratory disease, and constitute a health threat for immuno-compromised individuals. HAdV-Cs are well known for lysing cells, owing to the E3 CR1-β-encoded adenovirus death protein (ADP) ...

Minimum Error Calibration and Normalization for Genomic Copy Number Analysis

Background: Copy number variations (CNV) are regional deviations from the normal autosomal bi-allelic DNA content. While germline CNVs are a major contributor to genomic syndromes and inherited diseases, the majority of cancers accumulate extensive "somatic" CNV (sCNV or CNA) during the process of oncogenetic transformation and progression ...