Publications

Selected publications from the Greber lab (1993 - 2022)

 

 

jcs.252544
jcs.252544

 High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections

Olszewski D, Georgi F, Murer L, Andriasyan V, Kuttler F, Petkidis A, Witte R, Yakimovich A, Fischer L, Rozanova A, Yamauchi Y, Turcatti G, Greber UF (2022)

Sci Data. 2022 Oct 8;9(1):610. doi: 10.1038/s41597-022-01733-4

https://www.nature.com/articles/s41597-022-01733-4

 

    

 

 


 

jcs.252544
jcs.252544

Methylene blue, Mycophenolic acid, Posaconazole, and Niclosamide inhibit SARS-CoV-2 Omicron variant BA.1 infection of human airway epithelial organoids

Volle R, Murer L, Petkidis A, Andriasyan V, Savi A, Bircher C, Meili N, Fischer L, Sequeira DP, Mark DK, Gomez-Gonzalez A, Greber UF (2022)


Curr Res Microb Sci, 2022;3:100158

https://www.sciencedirect.com/science/article/pii/S2666517422000554

 

    

 

 


 

jcs.252544
jcs.252544

Sequence-specific features of short double-strand, blunt-end RNAs have RIG-I- and type 1 interferon-dependent or –independent anti-viral effects.

Kannan, A., Suomalainen, M., Volle, R., Bauer, M., Amsler, M., Trinh, H.V., Vavassori, S., Pachlopnik Schmid, J., Vilhena, G., Marín González, A., Perez, R., Franceschini, A., von Mering, C. Hemmi, S. & Greber, U.F. (2022).

Viruses, 14(7), 1407,
https://www.mdpi.com/1999-4915/14/7/1407/htm

    

 


 

jcs.252544
jcs.252544

Adenovirus Entry - Stability, Uncoating and Nuclear Import
Greber, UF & Suomalainen, M (2022)
Molecular Microbiology
10.1111/mmi.14909
PMID: 35434852
https://onlinelibrary.wiley.com/doi/10.1111/mmi.14909?af=R

 

 


 

jcs.252544
jcs.252544

Identification of broad anti-coronavirus chemical agents for repurposing against SARS CoV 2 and variants of concern.
L Murer, R Volle, V Andriasyan, A Petkidis, A Gomez-Gonzalez, L Yang, N Meili, M Suomalainen, M Bauer, D Sequeira, D Olszewski, F Georgi, F Kuttler, G Turcatti, UF Greber
Current Research in Virological Science, 3, 100019, doi.org/10.1016/j.crviro.2022.100019
PMID: 35072124
https://www.sciencedirect.com/science/article/pii/S2666478X22000010?via%3Dihub

 

 


 

jcs.252544
jcs.252544

A viral ubiquitination switch attenuates innate immunity and triggers nuclear import of virion DNA and infection.
Bauer M, Gomez-Gonzalez A, Suomalainen M, Schilling N, Hemmi S, Greber UF.
Sci Adv. 2021 Dec 17;7(51):eabl7150. doi: 10.1126/sciadv.abl7150. Epub 2021 Dec 17. PMID: 34919430
https://www.science.org/doi/10.1126/sciadv.abl7150


Featured in UZH News:
https://www.media.uzh.ch/en/Press-Releases/2021/Adenovirus-DNA-Transfer.html

 

 


 

jcs.252544
jcs.252544

Urs F Greber
Febs Letters, PMID: 34787897, DOI: https://doi.org/10.1002/1873-3468.14226

 https://pubmed.ncbi.nlm.nih.gov/34787897

 

 


 

jcs.252544
jcs.252544

Murer L.,  Petkidis A.,  Vallet T.,  Vignuzzi M. &  Greber U.F.
J Virol. 2021 Oct 27; JVI0106021; PMID: 34705560;DOI: 10.1128/JVI.01060-21

https://journals.asm.org/doi/10.1128/JVI.01060-21

 

 


 

jcs.252544
jcs.252544

Suomalainen, M. & Greber, U.F.

Viruses 2021, 13(8), 1568;

https://doi.org/10.3390/v13081568

 


 

jcs.252544
jcs.252544

Vardan Andriasyan, Artur Yakimovich, Anthony Petkidis, Fanny Georgi, Robert Witte, Daniel Puntener & Urs F. Greber

iScience, June 2021: doi.org/10.1016/j.isci.2021.102543

https://www.cell.com/action/showPdf?pii=S2589-0042(21)00511-3https://www.cell.com/action/showPdf?pii=S2589-0042(21)00511-3

 


 

jcs.252544
jcs.252544

Greber, U.F. & Gomez-Gonzalez, A. Adenovirus – a blueprint for gene delivery.
Curr Op Virol 2021, April 21, Vol 48, 49-56
www.sciencedirect.com/science/article/pii/S1879625721000225

 

 

 


 

jcs.252544
jcs.252544

Prasad, V. & Greber, U.F. The endoplasmic reticulum unfolded protein response – homeostasis, cell death and evolution in virus infections.
FEMS Microbiol Rev. 2021 Mar 25:fuab016. doi: 10.1093/femsre/fuab016
 

 


 

jcs.252544
jcs.252544

 

 

Suomalainen, M., Prasad, V., Kannan, A. & Greber, U.F. Cell-to-cell and genome-to-genome variability of Adenovirus transcription tuned by the cell cycle.
J Cell Sci. 2020 https://jcs.biologists.org/content/early/2020/09/10/jcs.252544.long

 


 

drug screen
drug screen

Georgi, F., Kuttler, F., Murer, L., Andriasyan, V., Witte, R., Yakimovich, A., Turcatti, G. & Greber, U. F. (2020) High-content image-based drug screen identifies a clinical compound against cell transmission of adenovirus. 

Sci Data. 2020 Aug 12;7(1):265. doi: 10.1038/s41597-020-00604-0. PMID: 32788590

https://www.nature.com/articles/s41597-020-00604-0

 


 

drug screen
drug screen

 

 

Georgi F, Andriasyan V, Witte R, Murer L, Hemmi S, Yu L, Grove M, Meili N, Kuttler F, Yakimovich A, Turcatti G, Greber UF. The FDA-approved drug Nelfinavir inhibits lytic cell-free, but not cell-associated non-lytic transmission of human adenovirus.
Antimicrob Agents Chemother. 2020 Jun 29: AAC.01002-20.
doi: https://aac.asm.org/content/early/2020/06/23/AAC.01002-20

 


 

Adenovirus
Adenovirus

Greber UF. 2020. Adenoviruses - Infection, pathogenesis and therapy. FEBS Lett doi:10.1002/1873-3468.13849

 

 


 

UPR sensor
UPR sensor

 

Prasad V, Suomalainen M, Jasiqi Y, Hemmi S, Hearing P, Hosie L, Burgert HG, Greber UF. 2020. The UPR sensor IRE1alpha and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections. Nat Commun 11:1997. doi: 10.1038/s41467-020-15844-2

 


 

E3 Ubiquitin
E3 Ubiquitin

 

 

Bauer M, Flatt JW, Seiler D, Cardel B, Emmenlauer M, Boucke K, Suomalainen M, Hemmi S, & Greber UF (2019). The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex. Cell Reports 29, 3785-3795. doi: 10.1016/j.celrep.2019.11.064

 


 

lung macrophage
lung macrophage

 

Stichling N, Suomalainen M, Flatt JW, Schmid M, Pacesa M, Hemmi S, Jungraithmayr W, Maler MD, Freudenberg MA, Plückthun, A, May T, Köster M, Fejer G & Greber UF (2018). Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus-type specific virus entry receptor. PloS Path 14(3):e1006914. doi: 10.1371/journal.ppat.1006914

 


 

co-option of membrane wounding
co-option of membrane wounding

 

 

 

Luisoni S, Suomalainen M, Boucke K, Tanner LB, Wenk MR, Guan XL, Grzybek M, Coskun U, & Greber UF (2015) Co-option of Membrane Wounding Enables Virus Penetration into Cells. Cell Host & Microbe 18 (1):75-85. doi:10.1016/j.chom.2015.06.006

 


 

Rhinovirus
Rhinovirus

 

Roulin, P., Lotzerich M, Tanner LB, Torta FT, van Kuppefeld F, Wenk MR, & Greber UF (2014). A Phosphatidylinositol 4-Phosphate and Cholesterol Counter-Current Model for the Formation of Rhinovirus Replication Compartments at ER-Golgi Interface. Cell Host & Microbe 16, 677-90. doi: 10.1016/j.chom.2014.10.003

 

 


 

tracking viral genomes
tracking viral genomes

 

 

Wang IH, Suomalainen M, Andriasyan V, Kilcher S, Mercer J, Neef A, Luedtke NW, & Greber UF (2013) Tracking viral genomes in host cells at single-molecule resolution. Cell Host & Microbe 14 (4):468-480. doi:10.1016/j.chom.2013.09.004

 


 

kinesin-1-mediated apsid disassembly
kinesin-1-mediated apsid disassembly

 

Strunze, S., Engelke, M.F., Wang, I.H., Puntener, D., Boucke, K., Schleich, S., Way, M., Schoenenberger, P., Burckhardt, C.J., and Greber, U.F. (2011). Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection. Cell Host Microbe 10, 210-223. doi: 10.1016/j.chom.2011.08.010

 

 


 

drifting motions of adenovirus
drifting motions of adenovirus

 

 

Burckhardt CJ, Suomalainen M, Schoenenberger P, Boucke K, Hemmi S, & Greber UF (2011) Drifting motions of the adenovirus receptor CAR and immobile integrins initiate virus uncoating and membrane lytic protein exposure. Cell Host & Microbe 10 (2):105-117. doi:10.1016/j.chom.2011.07.006

 


 

chemotactic anti-viral cytokines
chemotactic anti-viral cytokines

 

 

Lütschg V, Boucke K, Hemmi S & Greber UF (2011). Chemotactic anti-viral cytokines promote infectious apical entry of human adenovirus into polarized epithelial cells. Nature Comm. 2, 391. doi: 10.1038/ncomms1391

 


 

subversion of CtBP1
subversion of CtBP1

 

 

 

 

Amstutz B, Gastaldelli M, Imelli N, Kälin S, Boucke K, Wandeler E, Mercer J, Hemmi S & Greber UF (2008). Subversion of CtBP1 controlled macropinocytosis by human Adenovirus serotype 3. EMBOJ. 27, 956-66. doi: 10.1038/emboj.2008.38

 

 


 

import adenovirus dna
import adenovirus dna

 

Trotman L, Mosberger N, Fornerod M, Stidwill RP & Greber UF (2001). Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1. Nature Cell Biol., 3, 1092-1100. doi: 10.1038/ncb1201-1092

 


 

adenovirus 2
adenovirus 2

 

Greber UF, Willetts M, Webster P, & Helenius A (1993) Stepwise dismantling of adenovirus 2 during entry into cells. Cell 75 (3):477-486. doi: 0092-8674(93)90382-Z [pii]