Publications

Selected publications from the Greber lab (1993 - 2022)

 

 

jcs.252544
jcs.252544

Identification of broad anti-coronavirus chemical agents for repurposing against SARS CoV 2 and variants of concern.
L Murer, R Volle, V Andriasyan, A Petkidis, A Gomez-Gonzalez, L Yang, N Meili, M Suomalainen, M Bauer, D Sequeira, D Olszewski, F Georgi, F Kuttler, G Turcatti, UF Greber
Current Research in Virological Science, 3, 100019, doi.org/10.1016/j.crviro.2022.100019
PMID: 35072124
https://www.sciencedirect.com/science/article/pii/S2666478X22000010?via%3Dihub

 

 


 

jcs.252544
jcs.252544

A viral ubiquitination switch attenuates innate immunity and triggers nuclear import of virion DNA and infection.
Bauer M, Gomez-Gonzalez A, Suomalainen M, Schilling N, Hemmi S, Greber UF.
Sci Adv. 2021 Dec 17;7(51):eabl7150. doi: 10.1126/sciadv.abl7150. Epub 2021 Dec 17. PMID: 34919430
https://www.science.org/doi/10.1126/sciadv.abl7150


Featured in UZH News:
https://www.media.uzh.ch/en/Press-Releases/2021/Adenovirus-DNA-Transfer.html

 

 


 

jcs.252544
jcs.252544

Urs F Greber
Febs Letters, PMID: 34787897, DOI: https://doi.org/10.1002/1873-3468.14226

 https://pubmed.ncbi.nlm.nih.gov/34787897

 

 


 

jcs.252544
jcs.252544

Murer L.,  Petkidis A.,  Vallet T.,  Vignuzzi M. &  Greber U.F.
J Virol. 2021 Oct 27; JVI0106021; PMID: 34705560;DOI: 10.1128/JVI.01060-21

https://journals.asm.org/doi/10.1128/JVI.01060-21

 

 


 

jcs.252544
jcs.252544

Suomalainen, M. & Greber, U.F.

Viruses 2021, 13(8), 1568;

https://doi.org/10.3390/v13081568

 


 

jcs.252544
jcs.252544

Vardan Andriasyan, Artur Yakimovich, Anthony Petkidis, Fanny Georgi, Robert Witte, Daniel Puntener & Urs F. Greber

iScience, June 2021: doi.org/10.1016/j.isci.2021.102543

https://www.cell.com/action/showPdf?pii=S2589-0042(21)00511-3https://www.cell.com/action/showPdf?pii=S2589-0042(21)00511-3

 


 

jcs.252544
jcs.252544

Greber, U.F. & Gomez-Gonzalez, A. Adenovirus – a blueprint for gene delivery.
Curr Op Virol 2021, April 21, Vol 48, 49-56
www.sciencedirect.com/science/article/pii/S1879625721000225

 

 

 


 

jcs.252544
jcs.252544

Prasad, V. & Greber, U.F. The endoplasmic reticulum unfolded protein response – homeostasis, cell death and evolution in virus infections.
FEMS Microbiol Rev. 2021 Mar 25:fuab016. doi: 10.1093/femsre/fuab016
 

 


 

jcs.252544
jcs.252544

 

 

Suomalainen, M., Prasad, V., Kannan, A. & Greber, U.F. Cell-to-cell and genome-to-genome variability of Adenovirus transcription tuned by the cell cycle.
J Cell Sci. 2020 https://jcs.biologists.org/content/early/2020/09/10/jcs.252544.long

 


 

drug screen
drug screen

Georgi, F., Kuttler, F., Murer, L., Andriasyan, V., Witte, R., Yakimovich, A., Turcatti, G. & Greber, U. F. (2020) High-content image-based drug screen identifies a clinical compound against cell transmission of adenovirus. 

Sci Data. 2020 Aug 12;7(1):265. doi: 10.1038/s41597-020-00604-0. PMID: 32788590

https://www.nature.com/articles/s41597-020-00604-0

 


 

drug screen
drug screen

 

 

Georgi F, Andriasyan V, Witte R, Murer L, Hemmi S, Yu L, Grove M, Meili N, Kuttler F, Yakimovich A, Turcatti G, Greber UF. The FDA-approved drug Nelfinavir inhibits lytic cell-free, but not cell-associated non-lytic transmission of human adenovirus.
Antimicrob Agents Chemother. 2020 Jun 29: AAC.01002-20.
doi: https://aac.asm.org/content/early/2020/06/23/AAC.01002-20

 


 

Adenovirus
Adenovirus

Greber UF. 2020. Adenoviruses - Infection, pathogenesis and therapy. FEBS Lett doi:10.1002/1873-3468.13849

 

 


 

UPR sensor
UPR sensor

 

Prasad V, Suomalainen M, Jasiqi Y, Hemmi S, Hearing P, Hosie L, Burgert HG, Greber UF. 2020. The UPR sensor IRE1alpha and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections. Nat Commun 11:1997. doi: 10.1038/s41467-020-15844-2

 


 

E3 Ubiquitin
E3 Ubiquitin

 

 

Bauer M, Flatt JW, Seiler D, Cardel B, Emmenlauer M, Boucke K, Suomalainen M, Hemmi S, & Greber UF (2019). The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex. Cell Reports 29, 3785-3795. doi: 10.1016/j.celrep.2019.11.064

 


 

lung macrophage
lung macrophage

 

Stichling N, Suomalainen M, Flatt JW, Schmid M, Pacesa M, Hemmi S, Jungraithmayr W, Maler MD, Freudenberg MA, Plückthun, A, May T, Köster M, Fejer G & Greber UF (2018). Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus-type specific virus entry receptor. PloS Path 14(3):e1006914. doi: 10.1371/journal.ppat.1006914

 


 

co-option of membrane wounding
co-option of membrane wounding

 

 

 

Luisoni S, Suomalainen M, Boucke K, Tanner LB, Wenk MR, Guan XL, Grzybek M, Coskun U, & Greber UF (2015) Co-option of Membrane Wounding Enables Virus Penetration into Cells. Cell Host & Microbe 18 (1):75-85. doi:10.1016/j.chom.2015.06.006

 


 

Rhinovirus
Rhinovirus

 

Roulin, P., Lotzerich M, Tanner LB, Torta FT, van Kuppefeld F, Wenk MR, & Greber UF (2014). A Phosphatidylinositol 4-Phosphate and Cholesterol Counter-Current Model for the Formation of Rhinovirus Replication Compartments at ER-Golgi Interface. Cell Host & Microbe 16, 677-90. doi: 10.1016/j.chom.2014.10.003

 

 


 

tracking viral genomes
tracking viral genomes

 

 

Wang IH, Suomalainen M, Andriasyan V, Kilcher S, Mercer J, Neef A, Luedtke NW, & Greber UF (2013) Tracking viral genomes in host cells at single-molecule resolution. Cell Host & Microbe 14 (4):468-480. doi:10.1016/j.chom.2013.09.004

 


 

kinesin-1-mediated apsid disassembly
kinesin-1-mediated apsid disassembly

 

Strunze, S., Engelke, M.F., Wang, I.H., Puntener, D., Boucke, K., Schleich, S., Way, M., Schoenenberger, P., Burckhardt, C.J., and Greber, U.F. (2011). Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection. Cell Host Microbe 10, 210-223. doi: 10.1016/j.chom.2011.08.010

 

 


 

drifting motions of adenovirus
drifting motions of adenovirus

 

 

Burckhardt CJ, Suomalainen M, Schoenenberger P, Boucke K, Hemmi S, & Greber UF (2011) Drifting motions of the adenovirus receptor CAR and immobile integrins initiate virus uncoating and membrane lytic protein exposure. Cell Host & Microbe 10 (2):105-117. doi:10.1016/j.chom.2011.07.006

 


 

chemotactic anti-viral cytokines
chemotactic anti-viral cytokines

 

 

Lütschg V, Boucke K, Hemmi S & Greber UF (2011). Chemotactic anti-viral cytokines promote infectious apical entry of human adenovirus into polarized epithelial cells. Nature Comm. 2, 391. doi: 10.1038/ncomms1391

 


 

subversion of CtBP1
subversion of CtBP1

 

 

 

 

Amstutz B, Gastaldelli M, Imelli N, Kälin S, Boucke K, Wandeler E, Mercer J, Hemmi S & Greber UF (2008). Subversion of CtBP1 controlled macropinocytosis by human Adenovirus serotype 3. EMBOJ. 27, 956-66. doi: 10.1038/emboj.2008.38

 

 


 

import adenovirus dna
import adenovirus dna

 

Trotman L, Mosberger N, Fornerod M, Stidwill RP & Greber UF (2001). Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1. Nature Cell Biol., 3, 1092-1100. doi: 10.1038/ncb1201-1092

 


 

adenovirus 2
adenovirus 2

 

Greber UF, Willetts M, Webster P, & Helenius A (1993) Stepwise dismantling of adenovirus 2 during entry into cells. Cell 75 (3):477-486. doi: 0092-8674(93)90382-Z [pii]