Dr. Kristina Mathews
Tel +41 44 635 31 65
Kristina is originally from Connecticut, located in the northeastern part of the United States. Upon completing her bachelor’s degree in engineering, she moved to Germany where spent a year as an exchange student at the University of Konstanz, followed by several years living in Heidelberg working as a technician in Dr. Matthias Hentze’s lab at the European Molecular Biology Laboratory. She returned to the US to join Prof. Trudi Schüpbach’s group at Princeton University as a graduate student in the Department of Molecular Biology. There, she was awarded her PhD for her work studying female sterile mutations that disrupt axis establishment during oogenesis in Drosophila melanogaster. In 2011, Kristina joined Prof. Monica Zwicky’s lab at the University of Zurich where she investigated the genetic underpinning of sexual size dimorphism in Drosophila, while also assisting in teaching of undergraduate laboratory courses.
Kristina joined the Brunner lab in October 2021 to support research aimed at further elucidating molecular mechanisms that drive cell and tissue shape changes during Drosophila embryogenesis.
Mathews, K and Zwicky, M (manuscript in progress) Neuronal Myc promotes organismal growth in a Sxl-dependent manner.
Mathews, K., Cavegn, M., and Zwicky, M. (2017) Sexual Dimorphism of Body Size Is Controlled by Dosage of the X-Chromosomal Gene Myc and by the Sex-Determining Gene tra in Drosophila
Pane, A., Wehr, K. and Schupbach, T. (2007) Zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline. Dev. Cell 6, 851-62.
Wehr, K. and Schupbach, T. (2006) Deadlock a novel protein of Drosophila, is required for germline maintenance, fusome morphogenesis and axial patterning in oogenesis and associates with centrosomes in the early embryo. Dev Bio 294, 406-417.
McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F. et al.(2000). A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 5, 299-309.
Norvell, A., Kelley, R. L., Wehr, K. and Schupbach, T. (1999). Specific isoforms of squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesis. Genes Dev 13, 864-76.
Paraskeva, E., Gray, N. K., Schlager, B., Wehr, K. and Hentze, M. W. (1999). Ribosomal pausing and scanning arrest as mechanisms of translational regulation from cap-distal iron-responsive elements. Mol Cell Biol 19, 807-16.
McKie, A. T., Wehr, K., Simpson, R. J., Peters, T. J., Hentze, M. W. and Farzaneh, F. (1998). Molecular cloning and characterisation of a novel duodenal-specific gene implicated in iron absorption. Biochem Soc Trans 26, S264.
Thermann, R., Neu-Yilik, G., Deters, A., Frede, U., Wehr, K., Hagemeier, C., Hentze, M. W. and Kulozik, A. E. (1998). Binary specification of nonsense codons by splicing and cytoplasmic translation. Embo J 17, 3484-94.
Leifer, D., Li, Y. L. and Wehr, K. (1997). Myocyte-specific enhancer binding factor 2C expression in fetal mouse brain development. J Mol Neurosci 8, 131-43.