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Cell invasion is an initiating event during tumor cell metastasis and an essential process during development. During vulval development, the uterine anchor cell (AC) breaches two basal laminae that separate the uterus from the epidermis and invades the underlying vulval epithelium. We are investigating the signals, by which the vulval precursor cells induce the anchor cell to invade into the vulval epithelium.
Key publications
Lattmann, Evelyn; Deng, Ting; Walser, Michael; Widmer, Patrizia; Rexha-Lambert, Charlotte; Prasad, Vibhu; Eichhoff, Ossia; Daube, Michael; Dummer, Reinhard; Levesque, Mitchell P; Hajnal, Alex
PLOS Biology. February 22, 2022.
The Caenorhabditis elegans homolog of the Evi1 proto-oncogene, egl-43, coordinates G1 cell cycle arrest with pro-invasive gene expression during anchor cell invasion.
Deng T, Stempor P, Appert A, Daube M, Ahringer J, Hajnal A, Lattmann E.
PLoS Genet. 2020 Mar 23;16(3):e1008470.
doi: 10.1371/journal.pgen.1008470.
eCollection 2020 Mar.
Morf MK, Rimann I, Alexander M, Roy P, Hajnal A.
Dev Biol. 2013 Feb 1;374(1):108-14.
doi: 10.1016/j.ydbio.2012.11.019.
Epub 2012 Nov 29.
PMID: 23201576 Free Article
Rimann I, Hajnal A.
Dev Biol. 2007 Aug 1;308(1):187-95.
Epub 2007 May 25.
PMID: 17573066 Free Article