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Department of Molecular Life Sciences Hajnal group

Anchor Cell invasion

A model for the initiation of tumor cell metastasis

Cell invasion is an initiating event during tumor cell metastasis and an essential process during development. During vulval development, the uterine anchor cell (AC) breaches two basal laminae that separate the uterus from the epidermis and invades the underlying vulval epithelium. We are investigating the signals, by which the vulval precursor cells induce the anchor cell to invade into the vulval epithelium.

 

Anchor cell mutants
AC invasion in a wild-type worm (top row). No breaching of the basal laminae in an AC invasion defective mutant (bottom row).

 

 

 

 

Key publications

 

Prolonging somatic cell proliferation through constitutive hox gene expression in C. elegans

Heinze SD, Berger S, Engleitner S, Daube M, Hajnal A.  
Nat Commun. 2023 Oct 27

 

A DNA replication-independent function of pre-replication complex genes during cell invasion in C. elegans

Lattmann E, Deng T, Walser M, Widmer P, Rexha-Lambert C, Prasad V, Eichhoff O, Daube M, Dummer R, Levesque MP, Hajnal A
PLOS Biology. 2022 February 22

 


The Caenorhabditis elegans homolog of the Evi1 proto-oncogene, egl-43, coordinates G1 cell cycle arrest with pro-invasive gene expression during anchor cell invasion.

Deng T, Stempor P, Appert A, Daube M, Ahringer J, Hajnal A, Lattmann E.
PLoS Genet. 2020 Mar 23

 

The Caenorhabditis elegans homolog of the Opitz syndrome gene, madd-2/Mid1, regulates anchor cell invasion during vulval development.

Morf MK, Rimann I, Alexander M, Roy P, Hajnal A.
Dev Biol. 2013 Feb 1

 

Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans.

Rimann I, Hajnal A.
Dev Biol. 2007 Aug 1

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